Scientific foundations
Published research informs our questions. These references do not establish the effectiveness of Synativ and do not imply collaboration or institutional affiliation.
Persistent pain & fibromyalgia
Reviews describe central pain-processing mechanisms relevant to fibromyalgia and nociplastic pain. They provide context for research questions, not proof of a particular manual protocol.
Research questions
Explore pain processing, activity tolerance and the feasibility of a gentle, progressive intervention.
Migraine & sensory processing
Migraine reviews describe a neurological condition involving sensory and pain processing. They do not show that cranial massage eliminates chronic migraine.
Research questions
Use migraine neuroscience to inform questions about sensory sensitivity and manual support.
Touch & body perception
Touch research distinguishes sensory discrimination and affective aspects of touch. Applying these insights to a clinical program requires separate evaluation.
Research questions
Explore how tactile input and body-focused attention could inform a structured clinical approach.
Nazia Karsan · Continuum
Rupak Thapa & Dennis Ang · Cleveland Clinic Journal of Medicine
Kathleen A. Sluka & Daniel J. Clauw · Neuroscience
Peter J. Goadsby et al. · Physiological Reviews
Francis McGlone, Johan Wessberg & Håkan Olausson · Neuron
Program development
The program is in its preparation phase. Protocol design, participation criteria, outcome measures and the analysis plan are to be finalized with scientific and clinical partners before implementation.
Strategic collaborationhaim@synativ-research.com